Publication: Chronic administration of thiamine
pyrophosphate decreases age-related
histological atrophic testicular changes and
improves sexual behavior in male Wistar rats
Authors
Hernández-Montiel, H. L. ; Vásquez López, C. M. ; González-Loyola, J. G. ; Vega-Anaya, G. C. ; Villagrán-Herrera, M. E. ; Gallegos-Corona, M. A. ; Saldaña, C. ; Ramos Gómez, M. ; García Horshman, P. ; García Solís, P. ; Solís-S, J. C. ; Robles-Osorio, M. L. ; Ávila-Morales, J. ; Varela-Echavarría, A. ; Paredes Guerrero, R.
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Aging is a multifactorial universal process
and constitutes the most important risk factor for
chronic-degenerative diseases. Although it is a natural
process, pathological aging arises when these changes
occur quickly and the body is not able to adapt. This is
often associated with the generation of reactive oxygen
species (ROS), inflammation, and a decrease in the
endogenous antioxidant systems, constituting a
physiopathological state commonly found in chronicdegenerative
diseases. At the testicular level, aging is
associated with tissue atrophy, decreased steroidogenesis
and spermatogenesis, and sexual behavior disorders.
This situation, in addition to the elevated generation of
ROS in the testicular steroidogenesis, provides a critical
cellular environment causing oxidative damage at
diverse cellular levels. To assess the effects of a
reduction in the levels of ROS, thiamine pyrophosphate
(TPP) was chronically administered in senile Wistar rats.
TPP causes an activation of intermediate metabolism
routes, enhancing cellular respiration and decreasing the
generation of ROS. Our results show an overall decrease
of atrophic histological changes linked to aging, with
higher levels of serum testosterone, sexual activity, and
an increase in the levels of endogenous antioxidant
enzymes in TPP-treated animals. These results suggest
that TPP chronic administration decreases the
progression of age-related atrophic changes by
improving the intermediate metabolism, and by
increasing the levels of antioxidant enzymes.
publication.page.subject
Citation
Histology and Histopathology, vol. 29, nº 6, (2014)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/