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Changes in Proteins in Saliva and Serum in Equine Gastric Ulcer Syndrome Using a Proteomic Approach

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dc.contributor.authorMuñoz-Prieto, Alberto
dc.contributor.authorContreras-Aguilar, Maria Dolores
dc.contributor.authorCerón, Jose Joaquín
dc.contributor.authorAyala de la Peña, Ignacio
dc.contributor.authorMartin-Cuervo, María
dc.contributor.authorGonzález-Sánchez, Juan Carlos
dc.contributor.authorJacobsen, Stine
dc.contributor.authorKuleš, Josipa
dc.contributor.authorBeletić, Anđelo
dc.contributor.authorRubić, Ivana
dc.contributor.authorMrljak, Vladimir
dc.contributor.authorTecles, Fernando
dc.contributor.authorHansen, Sanni
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2024-09-10T08:23:48Z
dc.date.available2024-09-10T08:23:48Z
dc.date.issued2022-05-02
dc.description© 2022. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Animals To access the final work, see DOI: https://doi.org/10.3390/ani12091169es
dc.description.abstractChanges in the salivary proteome in 12 horses with the two diseases included in equine gastric ulcer syndrome (EGUS), equine glandular gastric disease (EGGD) (n = 6) and equine squamous gastric disease (ESGD) (n = 6), were evaluated using a high-resolution LC-MS/MS analysis of TMT-labelled peptides and compared to 10 healthy control horses. Serum was also analysed for comparative purposes. The comparison between the horses with EGGD and controls showed significant changes in 10 salivary proteins, whereas 36 salivary proteins were differently abundant between ESGD and control groups. The most upregulated proteins in the case of EGGD were relatedto immune activation whereas, in horses with ESGD, the most significantly changed proteins were associated with squamous cell regulation and growth. Compared to serum, saliva showed a higher number of proteins with significant changes and a different pattern of changes. The proteins identified in our study, in addition to providing new information about the pathophysiological mechanisms in these diseases, could have the potential to be novel biomarkers for the diagnosis or monitoring of EGGD and ESGD.es
dc.formatapplication/pdfes
dc.format.extent16es
dc.identifier.citationAnimals 2022, 12, 1169
dc.identifier.doihttps://doi.org/10.3390/ani12091169
dc.identifier.issnElectronic: 2076-2615
dc.identifier.urihttp://hdl.handle.net/10201/143806
dc.languageenges
dc.publisherMDPIes
dc.relationThis research was funded by a grant from the Program for Research Groups of Excellence of the Seneca Foundation, Murcia, Spain (Grant 19894/GERM/15) and by the European Structural and Investment Funds (Grant Agreement KK.01.1.16.0004). A.M.-P. is funded by the University of Murcia through a postdoctoral grant (Margarita Salas) within the mark of “Ayudas en el marco del Programa para la Recualificación del Sistema Universitario Español” through the European Union Next Generation fund.es
dc.relation.publisherversionElectronic: 2076-2615es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHorsees
dc.subjectEGUSes
dc.subjectProteomicses
dc.subjectSalivaes
dc.subjectSerumes
dc.subjectEGGDes
dc.subjectESGDes
dc.titleChanges in Proteins in Saliva and Serum in Equine Gastric Ulcer Syndrome Using a Proteomic Approaches
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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