Publication: Different expression of protein kinase A (PKA) regulatory
subunits in normal and neoplastic thyroid tissues
Authors
Ferrero, Stefano ; Vaira, Valentina ; Del Gobbo, Alessandro ; Vicentini, Leonardo ; Bosari, Silvano ; Beck-Peccoz, Paolo ; Mantovan, Giovanna ; Spada, Anna ; Lania, Andrea G.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
http://doi.org/10.14670/HH-30.473
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info:eu-repo/semantics/article
Description
Abstract
The four regulatory subunits (R1A, R1B,
R2A, R2B) of protein kinase A (PKA) are differentially
expressed in several cancer cell lines and exert distinct
roles in both cell growth and cell differentiation control.
Mutations of the PRKAR1A gene have been found in
patients with Carney complex and in a minority of
sporadic anaplastic thyroid carcinomas. The aim of the
study was to retrospectively evaluate the expression of
different PKA regulatory subunits in benign and non
benign human thyroid tumours and to correlate their
expression with clinical phenotype.
Immunohistochemistry demonstrated a significant
increase in PRKAR2B expression in both differentiated
and undifferentiated (anaplastic) thyroid tumors in
comparison with normal thyroid tissues. Conversely, a
significant increase in PRKAR1A expression was only
demonstrated in undifferentiated thyroid carcinomas in
comparison with normal thyroid tissue and differentiated
thyroid tumors. In thyroid cancers without lymph nodal
metastases PRKAR1A expression was higher in tumours
of more than 2 cm in size (T2 and T3) compared to
smaller ones (T1).
In conclusion, our data shows that an increased
PRKAR1A expression is associated with aggressive and
undifferentiated thyroid tumors.
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Citation
Histology and Histopathology, Vol. 30, n.º 4 (2015)
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