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The function and regulation mechanism of piRNAs in human cancers

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dc.contributor.authorWu, Wu
dc.contributor.authorLu, Bing-feng
dc.contributor.authorJiang, Ru-qi
dc.contributor.authorChen, Shuo
dc.date.accessioned2023-01-24T08:59:08Z
dc.date.available2023-01-24T08:59:08Z
dc.date.issued2021
dc.description.abstractPiwi-interacting RNAs (piRNAs) are mainly expressed in mammalian germ cells, playing an important role in maintaining germtable line DNA integrity, inhibiting transposon transcription and translation, participating in heterochromatin formation, epigenetic regulation, and germ cell genesis. They combine with P-element induced wimpy testis (PIWI) proteins to form effector complexes known as piRNAinduced silencing complexes (pi-RISC) to regulate the gene silencing pathway. Recent evidence suggests that numerous piRNAs, with tumor-promoting and tumorsuppressing functions in cancer development, are dysregulated in tumor tissues, and are related to clinical prognosis. In the present review, we summarize the current state of knowledge on the function and regulatory mechanisms of piRNAs in the tumorigenesis and progression of cancer, providing evidence for the potential use of piRNAs in the diagnosis and clinical treatment of cancer.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology Vol. 36, nº8 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-323
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127743
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPIWI proteines
dc.subjectPIWI-interacting RNAes
dc.subjectpiRNA clusterses
dc.subjectPosttranscriptional gene silencinges
dc.subjectGenome defensees
dc.subjectNeoplasmes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe function and regulation mechanism of piRNAs in human cancerses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº8 (2021)