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MiT family translocation renal cell carcinomas: A 15th anniversary update.

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dc.contributor.authorGandhi, atin S.
dc.contributor.authorMalik, Faizan
dc.contributor.authorAmin, Mahul B.
dc.contributor.authorArgani, Pedram
dc.contributor.authorBahrami, Armita
dc.date.accessioned2022-11-02T16:44:12Z
dc.date.available2022-11-02T16:44:12Z
dc.date.issued2020
dc.description.abstractMicrophthalmia (MiT) family translocation renal cell carcinomas (RCCs) are a heterogeneous category of renal tumors which all express MiT transcription factors, typically from chromosomal translocation and rarely from gene amplification. This tumor family has two major subtypes [i.e., Xp11 translocation RCC and t(6;11) RCC] and several related neoplasms (i.e., TFEB amplification RCC and melanotic Xp11 translocation renal cancers). Increased understanding of the clinical, pathological, molecular and prognostic heterogeneity of these tumors, since their official recognition in 2004, provides the opportunity to identify prognostic biomarkers and to understand the reasons for tumor aggression. We will review the literature from the past 15 years and highlight the need for a greater understanding of the molecular mechanisms underpinning heterogeneous tumor behaviores
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 35, nº 2 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-159
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/125065
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRenal cell carcinomaes
dc.subjectTranslocation renal cell carcinomaes
dc.subjectTFE3es
dc.subjectTFEBes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMiT family translocation renal cell carcinomas: A 15th anniversary update.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº2 (2020)