Publication: Novel Re(I) complexes as potential selective theranostic agents in cancer cells and in vivo in Caenorhabditis elegans tumoral strains
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Date
2024-03-07
Authors
Marco, Alicia ; Ashoo, Pezhman ; Hernández García, Samanta ; Martínez-Rodríguez, Pedro ; Cutillas, Natalia ; Vollrath, Annette ; Jordan, Dustin ; Janiak, Christoph ; Ruiz, José ; Gandía Herrero, Fernando
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Publisher
American Chemical Society
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DOI
https://doi.org/10.1021/acs.jmedchem.3c01869
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info:eu-repo/semantics/article
Description
© 2024,The Authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Journal of Medicinal Chemistry. To access the final edited and published work see https://doi.org/10.1021/acs.jmedchem.3c01869
Abstract
A series of rhenium(I) complexes of the type fac-[Re(CO)3(N^N)L]0/+, Re1−Re9, was synthesized, where N^N =benzimidazole-derived bidentate ligand with an ester functionality and L = chloride or pyridine-type ligand. The new compounds demonstrated potent activity toward ovarian A2780 cancer cells. The most active complexes, Re7−Re9, incorporating 4-NMe2py, exhibited remarkable activity in 3D HeLa spheroids. The emission in the red region of Re9,which contains an electron-deficient benzothiazole moiety, allowed its operability as a bioimaging tool for in vitro and in vivo visualization. Re9effectivity was tested in two different C. elegans tumoral strains, JK1466and MT2124, to broaden the oncogenic pathways studied. The results showed that Re9 was able to reduce the tumor growth in both strains by increasing the ROS production inside the cells. Moreover, the selectivity of the compound toward cancerous cells was remarkable as it did not affect neither the development nor the progeny of the nematodes
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Citation
J.Med.Chem.2024,67,7891−7910
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