Publication: Expression pattern of cell cycle-related gene products in synovial stroma and synovial lining
in active and quiescent stages of rheumatoid arthritis
Authors
Helmchen, B. ; Weckauf, H. ; Ehemann, V. ; Wittmann, I. ; Meyer-Scholten, C. ; Berger, I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective: To investigate the expression
pattern of cell cycle related gene products in active and
quiescent Rheumatoid arthritis (RA). Methods: Synovial
tissue from 20 patients with active proliferative RA and
28 patients with RA in remission was
immunohistochemically examined for expression of p53,
p63, p21, p27, p16, cyclin D1, CDK4, RB, E2F, Ki-67
on tissue microarrays and by DNA flow cytometry for
cell cycle phases. Results: Elevated expression of p53
and p27 was found in synovial lining and in stromal cells
in proliferative active RA. In the remission stage this
finding was confined to the synovial lining. Most of the
cells were in the G0-phase. Ki-67 proliferation index
was maximum 10% in synovial cells. Conclusion: The
p53 pathway is activated in synovial cells in active RA
as well as in quiescent stage of disease. Differences in
the spatial expression pattern of proteins involved in the
p53 pathway in RA in remission compared to actively
proliferating RA reflect the phasic nature of the disease
and support in our opinion the concept of adaptive role
of p53 pathway in RA
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