Publication: Morphological analysis of mouse hepatitis virus A59-induced pathology with regard to viral receptor expression
Authors
Godfraind, C. ; Coutelier, J. P.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mouse hepatitis virus, stra in A59 (MHVA59), is a coronav irus that triggers in susceptible mice a
wide va riety of pathologies, including hepatitis, thymus
in vo luti o n, B lymph ocy te po lyc lona l ac ti va tio n a nd ,
after intra-cerebral inocul ation, transient demye lination.
One recepto r that med iates entry of the virus into ta rget
ce lls has bee n ide nti fied: it is a g lycopro te in of the
ca rc inoembryo nic a ntige n fa mil y, ca ll ed Bgpl a . Th e
ava il abi lit y of a ntibo di es recogni z ing th is mo lecul e
permits the analysis of its ce llular expression and of the
re lationship between receptor expression and pathology
induced by the virus. Bgpl a is fo und on epitheli al and
e ndo th e li a l ce lls as we ll as o n B lymph ocy tes a nd
macrophages. In the live r, Bgpl a expression correlates
we ll with infect ion of hepatocytes and endothelia l cells,
leading to the deve lopment of hepatitis. However, other
ce lls ex pressing this molecul e, such as centra l nervous
system endo the lia l cells, are not in fec ted by the virus.
T his o bserva ti o n may exp la in how th e bl ood-b ra in
barri er prevents d issemi natio n of MHV-AS9 from the
general circu lation into the brain. Thymi c atrophy results
fro m a pop tosis of imm a tur e do ubl e-positi ve T
lymphocy tes w hi c h mi g ht be ca use d in d irectl y by
in fec tion of a small propo rtio n of thymus epitheli al ce lls
that express Bgp I a ra ther than by in fec tio n of T cells
th at do no t express th e rece ptor. Fin all y, po lyc lo na l
ac ti va ti o n of B lym phocy tes, lead in g to in c rease d
secre tio n of anti bodies of the IgG2a isotype, involves a
cascade of events, including cy tokine secre tion, that may
result from the interaction of MHV-A59 with B cells and
macrophages that express Bgpl a. Therefore, aft er v iral
in fec ti o n , ce llul a r exp ressio n of Bg p la may have
d iffe re nt res ults: ce ll lysis; a lt e ra ti o n of ce llul a r
functions th at may lead to indirect dea th of other ce ll
ty pes, or resistance to in fec tion.
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Citation
Histology and histopathology, Vol. 13, nº 1 (1998)
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