Publication: An immunocytochemical study of effects of light deprivation on prolactin cells in the adenohypophysis of the golden hamster
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Date
1991
Authors
Seu-Mei Wang ; Chuen-Lan Liu
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Population ratio and morphology of
prolactin cells were studied by employing immunohistochemical
methods in the adenohypophysis of normal and
experimental golden hamsters of both sexes at 16 weeks
of age. Prolactin cells occupied 29% of the total
adenohypophyseal cells in the intact males exposed to 141
10 h lightldark schedule. After stimulation of the pineal
activity by blinding or exposure of males to continuous
darkness for eight weeks, prolactin cells became atrophic
and were reduced in population to 17% and 13%,
respectively. ~i n e a l e c t om~~r e v e ntot e sdo me extent the
effects of the above treatments; thus, prolactin cells
constituted 27% in the pinealectomized and blinded
hamsters, and 19% in the pinealectomized and darknesstreated
group; and their morphology was comparable
with that of the intact controls. Prolactin cells in the
normal females were apparently larger in size and more
numerous as compared with those of the normal males,
comprising 47% of cell population in the anterior
pituitary. In response to light deprivation, prolactin
cells were atrophic with a diminished cytoplasm and
decreased in cell number as reflected in the population
ratio of 27% in the blinded and 21% in the darknesstreated
groups. In pinealectomized females combined
with blinding or darkness-treatment, prolactin cells
contained an abundance of secretory granules in the cytoplasm and maintained the population ratio
comparable to that in the intact females.
The present study revealed that light deprivation
exerts an inhibitory effect on the secretory activity of
prolactin cells and also causes hypoplasia of prolactin
cells in the hamster adenohypophysis, the effects being
mediated by the pineal gland.
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