Publication: Hepatocyte-like cells in the pancreatic islets, study
Authors
Tsanadis, G. ; Kotoulas, Othon B. ; Lollis, D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective: To determine the existence of
hepatocyte-like cells in the human foetal pancreas. Study
design: Foetal pancreas was examined in parallel with
two experimental models involving pancreatic tissue
regeneration. Foetal pancreases (n=20; 10 to 18 weeks)
were obtained from spontaneous abortions and were
histologically examined using haematoxylin-eosin and
PAS staining. Tissues from food-deprived and copperdeficient
female Wistar rats were studied following Dpenicillamine
administration, and tissue from female
hamsters was evaluated following administration of a --
pancreatic carcinogen. Histological examination in
animal studies included haematoxylin-eosin staining.
and diaminobenzidine histochemistry. Results: The
presence of a characteristic cell-type whose morphology
was distinct from islets cells and exocrine pancreas cells
was observed in human foetal pancreatic islets. These
c ~ l l sw ere morphologically similar to hepatocyte-like
cells and were compatible to those observed in the
experimental models. Topographical relationships
suggest that these originate from stem cells which are
related to the pancreas duct cells. Conclusion: We
conclude that hepatocyte-like cells or precursors exist in
the human foetal pancreas.
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