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FAM107A inhibits invasion and migration of colorectal cancer by affecting EMT via the AKT pathway

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dc.contributor.authorZhenyu Dai
dc.contributor.authorWenhui Li
dc.contributor.authorJun Zhu
dc.contributor.authorChunlong Li
dc.contributor.authorRui Huang
dc.contributor.authorHaoguang Wan
dc.contributor.authorYue Liu
dc.contributor.authorLizhou Chen
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-07-02T10:21:19Z
dc.date.available2026-07-02T10:21:19Z
dc.date.issued2026
dc.description.abstractMetastasis of colorectal cancer (CRC) is the main cause of CRC-related mortality. FAM107A is widely expressed in various normal tissues. However, few studies have revealed the biological function of FAM107A in epithelial-mesenchymal transition (EMT) in human cancer cells, and the related molecular mechanisms and signaling cascades are completely unknown. Here, we found that FAM107A was abnormally expressed in human CRC tissues and cell lines. Further research has shown that overexpression of FAM107A through transfection weakened the expression level of EMT-related markers. In addition, our research results indicated that upregulation of FAM107A inhibited the AKT signaling cascade in human CRC cells, while AKT activators restored activation of p50, indicating that FAM107A may regulate EMT through AKT activation of p50. Our results suggest that FAM107A could be a potential target for the treatment of CRC.
dc.formatapplication/pdf
dc.format.extent10
dc.identifier.doihttps://doi.org/10.14670/HH-25-024
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/241102
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFAM107A
dc.subjectAKT
dc.subjectEMT
dc.subjectColorectal Cancer
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleFAM107A inhibits invasion and migration of colorectal cancer by affecting EMT via the AKT pathway
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº7, (2026)