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Expression feature and prognostic function of a novel immune checkpoint Siglec-15 in human colorectal cancer

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dc.contributor.authorLiang, Guodong
dc.contributor.authorZhou, Linyun
dc.contributor.authorFan, Yang
dc.contributor.authorDing, Run
dc.contributor.authorYang, Junrong
dc.contributor.authorXu, Li
dc.contributor.authorZhu, Yidan
dc.contributor.authorHuang, Wen
dc.date.accessioned2025-03-21T10:21:09Z
dc.date.available2025-03-21T10:21:09Z
dc.date.issued2025
dc.description.abstractBackground. Sialic acid-bound immuno-globulin lectin 15 (Siglec-15) plays an important role in the development of cancer. However, the association between Siglec-15 expression and clinicopathological characteristics of colorectal cancer (CRC) has not been fully investigated. Methods. In this present study, a number of bioinformatics analyses were performed to provide an overview and detailed characteristics of Siglec-15. Quantitative real-time polymerase chain reaction (qPCR), western blotting and immunohistochemistry analyses were conducted to characterize the expression of Siglec-15 in CRC. Kaplan-Meier survival and Cox regression analyses were performed to identify the prognostic parameters of CRC. Results. The results of bioinformatics analyses revealed the expression characteristics and prognostic roles of Siglec-15 in CRC. The data of qCPR, western blotting, and IHC analyses demonstrated that the expression of Siglec-15 in CRC tissues was significantly higher than that in non-cancerous tissues. Moreover, the expression level of Siglec-15 in CRC was significantly associated with lymph node metastasis (p=0.001), TNM stage (p=0.001), and overall survival (p=0.026). COX multi-factor analysis indicated that Siglec-15 expression (p=0.023) and tumor differentiation (p=0.003) were independent prognostic factors for CRC. Conclusions. Collectively, the data suggested that Siglec-15 expression may serve as a novel prognostic factor and Siglec-15 might be identified as an ideal candidate for immunotherapy in CRC treatment.es
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dc.format.extent14es
dc.identifier.citationHistology and Histopathology Vol. 40, nº04 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-801
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/151914
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSiglec-15es
dc.subjectColorectal canceres
dc.subjectPrognosises
dc.subjectImmunotherapyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression feature and prognostic function of a novel immune checkpoint Siglec-15 in human colorectal canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº4 (2025)