Publication: Expression of liver X receptors in normal and refractory carcinoma tissues of the human lung and pancreas
Authors
Kashiwagi, Korehito ; Yanagida, Mai ; Matsui, Daiki ; Tanaka, Mizuko ; Sugimoto, Kotaro ; Chen, Honglei ; Ichikawa Tomikawa, Naoki ; Marubashi, Shigeru ; Suzuki, Hiroyuki ; Chiba, Hideki
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-949
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info:eu-repo/semantics/article
Description
Abstract
Liver X receptors (LXRs) participate not
only in maintaining cholesterol homeostasis but also in
controlling cellular growth in many types of normal and
tumor cells. We previously reported that LXRα was
aberrantly expressed in human oral squamous cell
carcinoma (HOSCC) tissues and cell lines, and that LXR
stimulation led to significant reduction of proliferation
of HOSCC cells via accelerating cholesterol efflux.
Since LXRs and downstream proteins involved in
cholesterol metabolism could be also applied as
therapeutic targets in small cell lung carcinoma (SCLC)
and pancreatic ductal adenocarcinoma (PDAC), we
herein analyzed the distribution of LXR proteins in these
refractory cancers as well as in normal human lung and
pancreatic tissues. LXRβ was observed in ciliated
epithelial cells, bronchial gland epithelia, type II alveolar
epithelia and alveolar macrophages of the lung, and was
less expressed in bronchial basal cells and type I alveolar
epithelia. In addition, LXRβ was detected in epithelium
of the pancreatic duct and acinar cells of the pancreas,
and was weakly expressed in pancreatic islet cells. By
contrast, LXRα expression was restricted to alveolar
macrophages, and was not evident in any types of
epithelial cells in the lung and pancreas. We also
demonstrated that LXRβ but not LXRα was abundantly
expressed in nine cases of SCLC and twenty cases of
PDAC tissues. These findings provide basic information
for evaluating the efficacy of LXR-targeted treatment in
SCLC and PDAC
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Citation
Histology and Histopathology, Vol.33, nº5, (2018)
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