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Value of the combination of intraepithelial tumor-infiltrating lymphocyte density and the heterogeneity of density as a prognostic marker in stage III colorectal cancers

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dc.contributor.authorLingyan Jin
dc.contributor.authorHye Yeong Jin
dc.contributor.authorSeung Yeon Yoo
dc.contributor.authorNam-Yun Cho
dc.contributor.authorJeong Mo Bae
dc.contributor.authorJung Ho Kim
dc.contributor.authorHye Seung Lee
dc.contributor.authorGyeong Hoon Kang
dc.contributor.departmentSin departamento asociado
dc.date.accessioned2025-09-24T09:50:49Z
dc.date.available2025-09-24T09:50:49Z
dc.date.issued2025
dc.description.abstractTumor-infiltrating lymphocyte (TIL) density is both a prognostic and a predictive factor in colorectal cancer (CRC). Whether the heterogeneity of TIL density across the tumor plays an important role in the clinical outcome of CRC is not well known. Adjuvant chemotherapy-treated patients with stage III CRC were analyzed for survival according to TIL density and density heterogeneity, which were determined on CD8-immunostained slides using a machine learning method and by calculating the Simpson evenness index, respectively. High heterogeneity of the intraepithelial TIL density was found to be an independent prognostic factor, with a hazard ratio of 1.970 (1.207-3.215) in the multivariate analysis of recurrence-free survival. High heterogeneity was closely associated with a high T category, venous invasion, perineural invasion, and KRAS mutation. The combination of both intraepithelial TIL density and density heterogeneity was significantly associated with the prognosis of patients: low TIL density/high TIL heterogeneity showed hazard ratios of 3.284 (1.639- 6.578) and 4.176 (1.713-10.178) in the discovery and validation cohorts, respectively. Our findings suggest that the heterogeneity status of intraepithelial TIL density might help delineate patients with better vs. worse survival when combined with intraepithelial TIL density.
dc.formatapplication/pdf
dc.format.extent9
dc.identifier.citationHistology and Histopathology, Vol.40, nº9, (2025), pg.1367-1375
dc.identifier.doi10.14670/HH-18-864
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/159609
dc.languageeng
dc.publisherUniversidad de Murcia, Histología e Histopatología
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdjuvant chemotherapy
dc.subjectColorectal cancer
dc.subjectHeterogeneity
dc.subjectPrognosis
dc.subjectTumor-infiltrating lymphocyte
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleValue of the combination of intraepithelial tumor-infiltrating lymphocyte density and the heterogeneity of density as a prognostic marker in stage III colorectal cancers
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº9 (2025)