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Sex-dependent differences in the adverse renal changes induced by an early in life exposure to a high-fat diet.

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dc.contributor.authorMoreno Ayuso, Juan Manuel
dc.contributor.authorTapia, Antonio
dc.contributor.authorReverte, Virginia
dc.contributor.authorOltra, Lidia
dc.contributor.authorLlinás Más, María Teresa
dc.contributor.authorSalazar, Francisco Javier
dc.contributor.authorMartínez Cáceres, Carlos Manuel
dc.contributor.departmentFisiología
dc.date.accessioned2025-01-16T12:38:13Z
dc.date.available2025-01-16T12:38:13Z
dc.date.issued2019-02-01
dc.description© 2019, the American Physiological Society. This document is the Published version of a published work that appeared in final form in American Journal of Physiology. Renal Physiology. To access the final edited and published work see https://doi.org/10.1152/ajprenal.00394.2018es
dc.description.abstractThis study examines whether the intake of a high-fat diet very early in life leads to changes in arterial pressure and renal function and evaluates whether the mechanisms involved in these changes are sex-dependent. Experiments were performed in male and female Sprague-Dawley rats fed a normal or high-fat diet from weaning to 4 mo of age. This exposure to a high-fat diet lead to an angiotensin II-dependent elevation in arterial pressure and to significant increments in fat abdominal volume and plasma leptin that were similar in both sexes. In addition, the angiotensin II-induced increment in renal vascular resistance was greater ( P < 0.05) in male (106 ± 14%) and female (97 ± 15%) rats fed a high-fat diet than in rats fed a normal-fat diet (51 ± 8%). However, the high-fat intake during early life induced increments in albuminuria, interleukin-6, and infiltration of CD3 lymphocytes in the renal parenchyma that were greater ( P < 0.05) in male than in female rats. Other sex-dependent differences in response to high-fat intake were that adiponectin levels only decreased in females (21%, P < 0.05), and renal NF-κB expression only increased in males (31%, P < 0.05). In summary, the early exposure to a high-fat diet leads to angiotensin II-dependent arterial pressure elevations and to increments in abdominal fat and in the renal sensitivity to angiotensin II that are similar in both sexes. However, the mechanisms involved in the renal changes associated with early exposure to a high-fat diet are different in males and females.es
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dc.format.extent9es
dc.identifier.citationAmerican Journal Physiology Renal Physiology 316: F332-F340, 2019
dc.identifier.doihttps://doi.org/10.1152/ajprenal.00394.2018
dc.identifier.issnPrint: 1931-857X
dc.identifier.issnElectronic: 1522-1466
dc.identifier.urihttp://hdl.handle.net/10201/148621
dc.languageenges
dc.relationSubdirección General de Proyectos de Investigación del Ministerio de Economia y Competitividad (BFU2013-49098-R) y Fundación Séneca de la Comunidad Autónoma de Murcia (19422/PI/14)es
dc.relation.publisherversionhttps://journals.physiology.org/doi/full/10.1152/ajprenal.00394.2018es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEarly obesityes
dc.subjectHypertensiones
dc.subjectInflammationes
dc.subjectRenal functiones
dc.subjectSex dependentes
dc.titleSex-dependent differences in the adverse renal changes induced by an early in life exposure to a high-fat diet.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationa11bfbe4-fe50-4173-a96d-aa785375a6be
relation.isAuthorOfPublication.latestForDiscoverya11bfbe4-fe50-4173-a96d-aa785375a6be
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