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Transcription factors involved in development and progression of malignant melanoma

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dc.contributor.authorPoser, I.es
dc.contributor.authorBosserhoff, A.K.es
dc.date.accessioned2011-06-08T09:04:29Z
dc.date.available2011-06-08T09:04:29Z
dc.date.issued2004
dc.description.abstractUp to date many genes are known to be deregulated in tumor development and progression. Genes important in tumorigenesis belong to families such as proteases, kinases and receptors. However, an important family of proteins is rarely discussed: the mediators of transcriptional control, the transcription factors. Usually, changes in transcription factor expression or activity can lead to more than just one downstream modification, as transcription factors are higher, thinking in a hierarchical way of expression control. In this review we summarize the role of the transcription factors AP-1, AP-2alpha, CREB, CtBP, ETS-1, HMGB1, LEF/TCF/ß-catenin, MITF, NF?B, PAX3, SKI, Snail and STAT in carcinogenesis focusing on melanoma development and progressiones
dc.formatapplication/pdfes
dc.format.extent16es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21517
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMalignant melanomaes
dc.subjectMetastasises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTranscription factors involved in development and progression of malignant melanomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.19, nº 1 (2004)