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Cholinesterases are down-expressed in human colorectal carcinoma

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dc.contributor.authorMontenegro Arce, María Fernanda
dc.contributor.authorRuiz Espejo, Francisco
dc.contributor.authorCampoy, F. J.
dc.contributor.authorMuñoz Delgado, Encarnación
dc.contributor.authorPáez de la Cadena, M.
dc.contributor.authorRodríguez-Berrocal, F. J.
dc.contributor.authorVidal, C. J.
dc.contributor.departmentBioquímica y Biología Molecular A
dc.date.accessioned2026-03-01T16:13:06Z
dc.date.available2026-03-01T16:13:06Z
dc.date.copyright© 2006, Birkhäuser Verlag, Basel
dc.date.issued2006-08-11
dc.description.abstractThe aberrations of cholinesterase (ChE) genes and the variation of ChE activity in cancerous tissues prompted us to investigate the expression of ChEs in colorectal carcinoma. The study of 55 paired specimens of healthy (HG) and cancerous gut (CG) showed that acetylcholinesterase (AChE) activity fell by 32% and butyrylcholinesterase (BuChE) activity by 58% in CG. Abundant AChE-H, fewer AChE-T, and even fewer AChE-R and BuChE mRNAs were observed in HG, and their content was greatly diminished in CG. The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (GA2 ) and monomers (GA1) account for 69% of AChE activity. The identification of AChE-T and BuChE mRNAs justifies the occurrence in gut of A12, GH4 and PRiMA-containing GA4 AChE forms, besides GH4 , GA4 and GH1 BuChE. The down-regulation of ChEs might contribute to gut carcinogenesis by increasing acetylcholine availability and overstimulating muscarinic receptors.
dc.formatapplication/pdf
dc.format.extent8
dc.identifier.citationCell. Mol. Life Sci. 63, 2175–2182 (2006)
dc.identifier.doihttps://doi.org/10.1007/s00018-006-6231-3
dc.identifier.eissn1420-9071
dc.identifier.issn1420-682X
dc.identifier.urihttp://hdl.handle.net/10201/216621
dc.languageeng
dc.publisherSpringer
dc.relationFondo de Investigación Sanitaria (PI041504) y Fundación Séneca de Murcia (00636/PI/04).
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00018-006-6231-3
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCancer
dc.subjectCholinesterases
dc.subjectGlycosylphosphatidylinositol
dc.subjectGut
dc.subjectReal time PCR
dc.subject.odsObjetivo 3: Salud
dc.titleCholinesterases are down-expressed in human colorectal carcinoma
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublication.latestForDiscovery2d4e44e6-9dda-4146-8aef-fe0c6b5a8b8f
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