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Systemic immune and tumor marker profiles in ovarian and deep infiltrating endometriosis: associations with disease severity and symptom burden

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dc.contributor.authorMarín Sánchez, Pilar
dc.contributor.authorNebot, Ana
dc.contributor.authorGarcía-Izquierdo, Laura
dc.contributor.authorNieto-Meca, Lucía
dc.contributor.authorSánchez, Rocío
dc.contributor.authorMachado Linde, Francisco
dc.contributor.authorMartínez-Esparza Alvargonzález, María Concepción
dc.contributor.authorRamírez Pávez, Tamara Nadira
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-03-10T11:37:29Z
dc.date.available2026-03-10T11:37:29Z
dc.date.copyright© 2025 by the authors
dc.date.issued2025-10-01
dc.description.abstractEndometriosis is a chronic, estrogen-dependent inflammatory disease with heterogeneous clinical manifestations and uncertain systemic immune involvement. This study aimed to characterize peripheral immune profiles and circulating tumor markers in women with ovarian endometrioma (OE) and deep infiltrating endometriosis (DIE), and to explore their associations with disease severity, symptom burden, and physical health perception. Peripheral blood leukocyte subsets, plasma cytokines, and tumor markers (CA125, CA19-9, CEA, HE4) were analyzed in 146 patients and 50 healthy controls. OE was associated with increased monocyte counts and reduced neutrophil proportions, while DIE showed elevated levels of IL-8 and Galectin-1. IL-33 levels correlated negatively with the revised American Society for Reproductive Medicine (rASRM) scores and positively with neutrophil proportion, suggesting a role in systemic immune regulation. Tumor marker levels varied by subtype: CA19-9 was higher in OE, and CEA in DIE. CA125 correlated with disease severity, and CEA with monocyte levels. Exploratory heatmaps revealed consistent immune-tumor associations linked to anatomical severity and symptom profiles. Although exploratory, these findings highlight the presence of distinct systemic immune patterns in endometriosis and support the potential of integrative blood-based biomarkers for future diagnostic and stratification strategies.
dc.formatapplication/pdf
dc.format.extent22
dc.identifier.citationInt. J. Mol. Sci. 2025, 26, 9581
dc.identifier.doihttps://doi.org/10.3390/ijms26199581
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10201/219441
dc.languageeng
dc.publisherMDPI
dc.relationThis research was funded by Precipita from Fecyt (Fundación Española para la Ciencia y Tecnología), grant number PR294. TR-P was funded by a grant from the University of Murcia.
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/26/19/9581
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEndometriosis
dc.subjectDeep infiltrating endometriosis
dc.subjectPeripheral blood leukocytes
dc.subjectCytokines
dc.subjectTumor markers
dc.subjectInflammation
dc.subjectNon-invasive biomarkers
dc.subjectMonocytes
dc.subjectOvarian
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleSystemic immune and tumor marker profiles in ovarian and deep infiltrating endometriosis: associations with disease severity and symptom burden
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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