Publication:
PSMA expression on neovasculature of solid tumors

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dc.contributor.authorWiele, Christophe Van de
dc.contributor.authorSathekge, Mike
dc.contributor.authorSpiegeleer, Bart de
dc.contributor.authorJonghe, Pieter Jan De
dc.contributor.authorDebruyne, Philip R.
dc.contributor.authorBorms, Marleen
dc.contributor.authorBeels, Laurence
dc.contributor.authorMaes, Alex
dc.date.accessioned2022-12-07T08:18:23Z
dc.date.available2022-12-07T08:18:23Z
dc.date.issued2020
dc.description.abstractThe use of prostate specific membrane antigen (PSMA) binding agents, labelled with diagnostic and therapeutic radio-isotopes is opening the potential for a new era of personalized management of prostate carcinoma. A wide variety of immuno- histochemistry studies have shown PSMA also to be upregulated on the endothelial cells of the neovasculature of a wide variety of other solid tumors where it may facilitate endothelial cell sprouting and invasion through its regulation of lytic proteases that have the ability to cleave the extracellular matrix. Similar to the introduction of PSMA-targeting theranostics in prostate carcinoma, overexpression of PSMA on newly formed tumor vessels may serve as a target for imaging and subsequent treatment of cancer through the use of agents that are capable of blocking PSMA in its function or through PSMA-mediated delivery of chemotherapeutics or radiation agents. In this review, the available data on PSMA expression on tumor neovasculature in human solid tumors assessed by using immunohistochemistry are discussedes
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 35, nº9 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-215
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126203
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPSMAes
dc.subjectNeovasculaturees
dc.subjectSolid tumorses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePSMA expression on neovasculature of solid tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº9 (2020)