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Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury

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dc.contributor.authorNadal-Nicolás, Francisco Manuel
dc.contributor.authorGalindo Romero, Caridad
dc.contributor.authorValiente Soriano, Francisco Javier
dc.contributor.authorBarberà-Cremades, María
dc.contributor.authorTorre-Minguela, Carlos de
dc.contributor.authorSalinas Navarro, Manuel Ángel
dc.contributor.authorPelegrín Vivancos, Pablo
dc.contributor.authorAgudo Barriuso, Marta
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-01-27T20:09:02Z
dc.date.available2026-01-27T20:09:02Z
dc.date.issued2016-12-08
dc.description.abstractAxonal injury is a common feature of central nervous system insults that culminates with the death of the affected neurons, and an irreversible loss of function. Inflammation is an important component of the neurodegenerative process, where the microglia plays an important role by releasing proinflammatory factors as well as clearing the death neurons by phagocytosis. Here we have identified the purinergic signaling through the P2X7 receptor as an important component for the neuronal death in a model of optic nerve axotomy. We have found that in P2X7 receptor deficient mice there is a delayed loss of retinal ganglion cells and a decrease of phagocytic microglia at early times points after axotomy. In contralateral to the axotomy retinas, P2X7 receptor controlled the numbers of phagocytic microglia, suggesting that extracellular ATP could act as a danger signal activating the P2X7 receptor in mediating the loss of neurons in contralateral retinas. Finally, we show that intravitreal administration of the selective P2X7 receptor antagonist A438079 also delays axotomy-induced retinal ganglion cell death in retinas from wild type mice. Thus, our work demonstrates that P2X7 receptor signaling is involved in neuronal cell death after axonal injury, being P2X7 receptor antagonism a potential therapeutic strategy.
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dc.format.extent14
dc.identifier.citationSci Rep. 2016 Dec 8;6:38499
dc.identifier.doihttps://doi.org/10.1038/srep38499
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10201/195490
dc.languageeng
dc.publisherNature Research
dc.relationSpanish Ministry of Economy and Competitiveness: ISCIII-FEDER “Una manera de hacer Europa” PI13/00643 (MA-B); PI13/00174 (PP); European Research Council ERC-2013-CoG 614578 (PP).
dc.relation.publisherversionhttps://www.nature.com/articles/srep38499
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsObjetivo 3: Salud
dc.titleInvolvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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