Publication: Tissue remodelling in liver diseases
Authors
Giannelli, G. ; Quaranta, V. ; Antonaci, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Tissue remodelling is a dynamic process that
occurs during fetal or adult life and involves a
modification of the original organization and function of
a tissue. Tissue remodelling is observed in physiological
and pathological conditions such as during wound
healing or in the mammary gland during the course of
pregnancy. In this review we will discuss the
remodelling occurring in the liver as a consequence of
chronic inflammation, as observed in chronic hepatitis,
or as a consequence of hepatocellular carcinoma (HCC)
progression in more detail. We will consider how altered
deposition and turn-over of extracellular matrix (ECM)
proteins could lead to development of liver fibrosis, and
how the exacerbation of fibrosis could underlie the
development of cirrhosis. The involvement of
inflammatory and anti-inflammatory cytokines
commonly used as therapeutic agents, such as
Interferon-a, is then evaluated with a particular focus on
modulation of ECM proteolysis. Finally, we analyze the
role of alterations of the surrounding microenvironment
including ECM, growth factors, cytokines and
membrane receptors for ECM ligands in the
development of HCC and in its invasive behaviour.
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