Publication: Adhesion molecules as targets for cancer therapy
Authors
Huang, Y.W. ; Baluna, R. ; Vitetta, E.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Adhesion molecules mediate cell-cell and
cell-matrix interactions and are essential for numerous
physiological and pathological processes. Recent
evidence from many laboratories suggests that adhesion
molecules play an important role in tumor progression
and may promote tumor growth and organ-specific
metastasis. Certain adhesion molecules may also
function as tumor suppressors. In this review, we
describe current concepts concerning the role of the
adhesion molecules in the pathogenesis of cancer and the
development of therapeutic approaches which make use
of this information. Hence, by preventing tumor cells
from interacting with each other or with their microenvironment,
tumor growth and metastasis can be
suppressed. The feasibility of using anti-adhesion
strategies to treat cancer has been demonstrated in many
animal models. Thus, monoclonal antibodies (MAbs)
against adhesion molecules, synthetic peptidic and
nonpeptidic analogues of the recognition sequences on
their receptors, soluble adhesion molecules and antisense
oligonucleotides can inhibit tumor growth and gene
therapy can restore the functions of altered tumorsuppressive
adhesion molecules.
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