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Seroreactivity of crohn`s disease patients to mycobacterial antigens: original data and analytical review of early literature.

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dc.contributor.authorJuste, Ramón A.
dc.contributor.authorPortu, Joseba
dc.contributor.authorAldamiz, Mikel
dc.contributor.authorSáez de Ocáriz, Carmen
dc.contributor.authorRodrick, Chiodini
dc.contributor.otherFacultad de Veterinariaen_EN
dc.date.accessioned2009-03-16T11:13:10Z
dc.date.available2009-03-16T11:13:10Z
dc.date.issued2007
dc.description.abstractThe mycobacterial etiology of Crohn’s disease has longtime been the subject of discussion and several studies on this issue have been published. In this paper we set out to critically analyze reports on the humoral response against mycobacterial antigens among Crohn’s disease patients and matched samples of ulcerative colitis, tuberculosis, and healthy controls, published during the decade that followed initial suspicions in the early-mid 1980s. We also provide our own previously unpublished results of the humoral response of Crohn’s disease, ulcerative colitis, and tuberculosis patients and healthy controls to an adapted paratuberculosis (PPA- 3 antigen) ELISA. Our study indicate that statistical analysis of some studies were not adequate, and that a general signifi cantly (p<0.01) increased reactivity against mycobacterial antigens could be observed in the combined analysis of all available data (meta-analysis). The reactivity of Crohn’s patients did not signfi cantly differ from reactivity of tuberculosis patients against mycobacterial antigensen_EN
dc.formatapplication/pdfes
dc.format.extentp. 91-103en_EN
dc.identifier.issn0213-5434
dc.identifier.urihttp://hdl.handle.net/10201/3633
dc.languageengen_EN
dc.languagespaen_EN
dc.publisherMurcia, Universidad de Murcia, Servicio de Publicacionesen_EN
dc.relation.ispartofAnales de veterinaria de Murcia, vol. 23, 2007en_EN
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCrohnen_EN
dc.subjectColitis ulcerosa y tuberculosisen_EN
dc.subject.otherCDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pescaen_EN
dc.titleSeroreactivity of crohn`s disease patients to mycobacterial antigens: original data and analytical review of early literature.en_EN
dc.title.alternativeSeroreactividad de pacientes de la enfermedad de Crohn a antígenos micobacteriano: datos originales y revisión de los estudios pionerosen_EN
dc.typeinfo:eu-repo/semantics/articleen_EN
dspace.entity.typePublicationes
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Anales de veterinaria de Murcia Vol. 23 (2007)