The function of actin in gene transcription

Publication:
The function of actin in gene transcription

dc.contributor.author	Obrdlik, A.	es
dc.contributor.author	Kukalev, A.	es
dc.contributor.author	Percipalle, P.
dc.date.accessioned	2012-05-21T12:10:54Z
dc.date.available	2012-05-21T12:10:54Z
dc.date.issued	2007
dc.description.abstract	Recent developments in the field of gene transcription regulation have unfolded a key role for actin as an important co-factor for all three eukaryotic RNA polymerases. In this review article we discuss the latest findings on actin in transcription of protein-coding and ribosomal genes, in complex with specific hnRNP proteins and a form of myosin 1ß which is entirely localized to the cell nucleus. Based on these recent studies, we propose a general model where actin may function in basal gene transcription as an allosteric regulator, to recruit transcriptional co-activators on active genes. A future challenge will be the identification of the polymerization state of actin in gene transcription and how it is mechanistically regulated.
dc.format	application/pdf	es
dc.format.extent	5	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/27633
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Nuclear actin	es
dc.subject	Ribonucleoproteins	es
dc.subject.other	577 - Bioquímica. Biología molecular. Biofísica	es
dc.title	The function of actin in gene transcription	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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