Publication: Exploring ischemia-induced vascular lesions and
potential pharmacological intervention strategies
Authors
Aliev, G. ; Obrenovich, M.E. ; Seyidova, D. ; De la Torre, J.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Structural changes in vessels under the
influence of ischemia play an important role in the
pathogenesis of many diseases, most important of which
are stroke and myocardial infarction or myocardial
insult. Over the years, information has been gathered,
which implicate a role for ischemic vascular changes in
the pathogenesis of crush-syndrome, atherosclerosis and
other vascular diseases. When blood vessels are
damaged they become unresponsive to a stimulus, which
normally elicits vasodilatation and can lead to
intraluminal thrombosis and ischemic events. The aim of
this review is to explore the structural changes seen in
vessels affected by ischemia reperfusion injury. With
ischemia, the development of observable changes to
vascular structure is multifactorial. One key factor is
reperfusion ischemic injury. Moreover, the duration of
the ischemic event is an important factor when
determining both the prognosis and the type of
morphological change that is observable in affected
vessel walls. In this regard, the deleterious progression
of blood flow impairment and its severity depends on the
specific organ involved and the type of tissue affected.
Further, there are regional differences within affected
tissues and the degree of microvascular injury is well
correlated with differences in the nature and severity of
the ischemic event. Any method aimed at preventing and
treating ischemic reperfusion injuries in vessels, based
on these investigations, should likewise be able to
decrease the early signs of brain, cerebrovascular and
heart injury and preserve normal cellular architecture.
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