Publication: Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors
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Date
2001
Authors
Jin, Y. ; Lu, H. B. ; Liong, E. ; Lau, T. Y. H. ; Tipoe, G. L.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of our study was to document
whether relationships existed among bone
morphogenetic proteins (BMPs), peripheral nerve and
neoplastic lesions of nerve sheath tumors. The mRNA
transcriptions of BMP-2, 3, 4 and 5 in 10 cases of
schwannoma, three cases of malignant schwannoma and
two cases of trigeminal neuralgia were detected using an
in situ hybridization technique. Our results demonstrated
that the myelin sheaths of Schwann cell from the
pe ripheral neuroectomy of trigeminal neuralgia
positively expressed mRNA of BMP-2, 3, 4, and 5. The
most interesting finding was that the nerve fibers of
trigeminal nerve showed only BMP-2 positive staining.
All of the neoplastic lesions of nerve sheath showed a
consistent but variant expression of BMP-2, 3, 4, and 5.
The expression signals of BMP-2 , 3, 5 mRNA in
malignant schwannoma were relatively lower than in
benign lesions except for the expression of BMP-4
mRNA. Our results indicated that selected members of
BMPs were expressed in the peripheral nerves that might
contribute to the health maintenance, proliferation,
regeneration and neoplastic transformation of the
peripheral nerve system. Furthermore, the effects of
BMP-2, 3, 4 and 5 on peripheral nervous system during
neoplastic transformation might be widespread, diverse
and antagonistic.
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Citation
Histology and histopathology, Vol. 16, nº 4 (2001)
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