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Next-generation sequencing-based characterization of the invasion by anatomical contiguity in a primary osseous diffuse large B-cell lymphoma. Correlation between the genetic profile of the malignancy and the clinical outcome of the patient

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dc.contributor.authorZaharie, Florin
dc.contributor.authorPop, Laura-Ancuta
dc.contributor.authorPetrushev, Bobe
dc.contributor.authorJurj, Ancuta
dc.contributor.authorMuresan, Mihai-Stefan
dc.contributor.authorEniu, Dan
dc.contributor.authorFetica, Bogdan
dc.contributor.authorPetkov, Bozhidar
dc.contributor.authorPasca, Sergiu
dc.contributor.authorPiciu, Doina
dc.contributor.authorRus, Ioana
dc.contributor.authorDeak, Dalma
dc.contributor.authorDima, Delia
dc.contributor.authorDesmirean, Minodora-Silvia
dc.contributor.authorTomuleasa, Ciprian
dc.contributor.authorBerindan-Neagoe, Ioana
dc.date.accessioned2022-07-01T11:13:18Z
dc.date.available2022-07-01T11:13:18Z
dc.date.issued2019
dc.description.abstractPrimary bone lymphoma is now a welldescribed entity in the World Health Organization (WHO) Classification of Tumors of Soft Tissue and Bone as a malignancy of the lymphoid tissue, with at least one mass within bone, without involvement of supraregional lymph nodes or other extranodal sites. In the current paper, we describe the complete characterization of the mutational landscape of a diffuse large B cell non-Hodgkin's lymphoma (DLBLCL) of the tibial plateau. Currently, there is very little data about the genetic landscape of primary osseous lymphomas and about the genetic background of this type of malignancy, resistant to chemotherapy and invading the surrounding tissues. In the current paper, we describe the complete characterization of the mutational landscape of a DLBCL of the tibial plateau. Our data is consistent with already published data, that have shown that MKI67 activation is correlated with lymphoma progression. Along with a high Ki67 index, resistance to chemotherapy occurs with neurogenic locus notch homolog protein 1 (Notch) and KRAS activation. This is the first molecular characterization for the invasion by anatomical contiguity for a primary bone lymphoma and while we only characterized one case and further deep sequencing analyses are required, we can explain the clinical dismal evolution of the patient by correlating them with the genetic landscape of this type of lymphoma.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.34, nÂş6, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-067
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/122010
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPrimary non-Hodgkin's lymphoma of the tibial plateaues
dc.subjectInvasion by contiguityes
dc.subjectNGS-based characterizationes
dc.subjectResistance to chemotherapyes
dc.subjectClinical correlationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleNext-generation sequencing-based characterization of the invasion by anatomical contiguity in a primary osseous diffuse large B-cell lymphoma. Correlation between the genetic profile of the malignancy and the clinical outcome of the patientes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nÂş6 (2019)