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Sex-dependent hypertension and renal changes in aged rats with altered renal development

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dc.contributor.authorSaez, Fara
dc.contributor.authorReverte, Virginia
dc.contributor.authorPaliege, Alexander
dc.contributor.authorMoreno, Juan Manuel
dc.contributor.authorLlinás Más, María Teresa
dc.contributor.authorBachmann, Sebastían
dc.contributor.authorSalazar, Francisco Javier
dc.contributor.departmentFisiología
dc.date.accessioned2025-03-17T13:06:32Z
dc.date.available2025-03-17T13:06:32Z
dc.date.issued2014-08-15
dc.description© 2014 the American Physiological Society. This document is the Published version of a Published Work that appeared in final form in American Journal of Physiology - Renal Physiology. To access the final edited and published work see https://doi.org/10.1152/ajprenal.00198.2014
dc.description.abstractNumerous studies have evaluated blood pressure (BP) and renal changes in several models of developmental programming of hypertension. The present study examined to what extent BP, renal hemodynamic, and renal structure are affected at an old age in male and female animals with altered renal development. It also evaluated whether renal damage is associated with changes in cyclooxygenase (COX)-2 and neuronal nitric oxide synthase (NOS1) expression and immunoreactivity. Experiments were carried out in rats at 10–11 and 16–17 mo of age treated with vehicle or an ANG II type 1 receptor antagonist during the nephrogenic period (ARAnp). A progressive increment in BP and a deterioration of renal hemodynamics were found in both sexes of ARAnp-treated rats, with these changes being greater (P < 0.05) in male rats. The decrease in glomerular filtration rate at the oldest age was greater (P < 0.05) in male (74%) than female (32%) ARAnp-treated rats. Sex-dependent deterioration of renal structure was demonstrated in optical and electron microscopic experiments. COX-2 and NOS1 immunoreactivity were enhanced in the macula densa of male but not female ARAnp-treated rats. The present study reports novel findings suggesting that stimuli that induce a decrease of ANG II effects during renal development lead to a progressive increment in BP and renal damage at an old age in both sexes, but these BP and renal changes are greater in males than in females. The renal damage is associated with an increase of COX-2 and NOS1 in the macula densa of males but not females with altered renal development.es
dc.formatapplication/pdfes
dc.format.extent10
dc.identifier.citationAmerican Journal of Physiology-Renal Physiology, 307(4), F461-F470
dc.identifier.doihttps://doi.org/10.1152/ajprenal.00198.2014
dc.identifier.issnPrint: 1931-857X
dc.identifier.issnElectronic: 1522-1466
dc.identifier.urihttp://hdl.handle.net/10201/151803
dc.languageenges
dc.relationThis work was supported by Dirección General de Investigación Cientifica y Técnica of Ministerio de Economia y Competitividad (BFU2013-49098R) and by Fundación Séneca from Comunidad Autónoma of Murcia Grant 08777/PI/08.es
dc.relation.publisherversionhttps://journals.physiology.org/doi/full/10.1152/ajprenal.00198.2014
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHypertension
dc.subjectFetal programming
dc.subjectRenal damage
dc.subjectAging
dc.subjectSex differences
dc.subjectCyclooxygenase 2
dc.subjectNeuronal nitric oxide synthase
dc.titleSex-dependent hypertension and renal changes in aged rats with altered renal developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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