Publication:
Steroid receptors in human ejaculated sperm as molecular markers of the detrimental effects related to the pathophysiology of testicular varicocele

Simple item page
dc.contributor.authorPerrotta, Ida
dc.contributor.authorAquila, Saveria
dc.date.accessioned2021-10-20T11:34:34Z
dc.date.available2021-10-20T11:34:34Z
dc.date.issued2016
dc.description.abstractThe exact physiopathologic effect of testicular varicocele on male fertility is not defined yet. The detrimental role of the varicocele in fertility is supported by the presence of a higher frequency of affected men among the infertile population. However, the mechanism/s by which a varicocele impairs sperm production, structure and function, is not known. In spite of active interest, our understanding of the human male gamete ultrastructural molecular organisation is still incomplete and therefore our knowledge of the sperm molecular anatomy is very limited. The presence of steroid binding sites on human spermatozoa has been evidenced since the 1970s, and afterwards, spermatozoa physiology was linked to the action of different steroids. The presence of steroid/steroid receptor systems was demonstrated in mature spermatozoa as membrane but also as nuclear conventional receptors, suggesting that both systemic and local steroids, through sperm receptors, may influence male fertility. From new data, it emerges that varicocele may induce damage in the male gamete at molecular level, opening a new chapter in the already multifactorial pathophysiology of the varicocele, complicating this issue. In sperm from varicocele, a decreased expression of steroid receptors and a consequent reduced responsiveness to steroids may represent a mechanism involved in the physiopathology of varicocele. Therefore, the modulation of these nuclear receptors pave the way for novel therapeutic opportunities in the treatment of the male pathologies related to human reproduction. The purpose of this review is to gain new insight into the physiopathology of varicocele and to study its impact on human sperm molecular anatomyes
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.citationHistology and Histopathology, Vol.31, nÂş8, (2016)
dc.identifier.doiDOI: 10.14670/HH-11-761
dc.identifier.issn0213-3911
dc.identifier.issn1699-5858
dc.identifier.urihttp://hdl.handle.net/10201/113104
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEstrogen receptorses
dc.subjectProgesterone receptorses
dc.subjectAndrogen receptorses
dc.subjectSteroidses
dc.subjectVaricocelees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleSteroid receptors in human ejaculated sperm as molecular markers of the detrimental effects related to the pathophysiology of testicular varicocelees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Perrotta-31-819-831-2016.pdf
Size:
2.36 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.31, nÂş8 (2016)