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Tumor-infiltrating lymphocytes expressing IOT-10 marker. An immunohistochemical study of a series of 185 brain tumors

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Tumorinfiltrating lymphocytes expressing IOT10 marker. An immunohistochemical study of a series of 185 brain tumors.pdf(3.53 MB)
Date
1993
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Authors
Zurita, M. ; Vaquero, J. ; Coca, S. ; Oya, S. ; García, N .
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The presence of IOT-10-positive lymphocytes among the tumor-infiltrating-lymphocyte (TIL) population was studied in a series of 185 brain tumors. In most of the tumors, IOT-10-positive lymphocytes were identified, but generally they were scarce and masked among the tumor cells, suggesting that NK-cells exercise a poor participation in the tissular response against brain tumors. Isolated tumor cells showing IOT- 10-positivity were found in low-grade astrocytomas, neurinomas and medulloblastomas. IOT- 10-positivity on both tumor neuropil and tumor cells was considered a characteristic finding in oligodendrogliomas. The number of IOT- 10-positive NK-cells in brain metastases and in cerebellar hemangioblastomas was comparatively greater than in other types of brain tumor. Since in brain metastases, the presence of IOT-10-positive NK-cells can be related to the tissular response to an extracerebral malignancy, their considerable presence in cerebellar hemangioblastomas is an enigmatic finding that desemes further attention.
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Immunohistochemistry , Brain tumors
Citation
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http://hdl.handle.net/10201/18404
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Histology and histopathology Vol. 8, nº 2 (1993)
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