Publication: The yin-yang of PR-domain family genes in tumorigenesis
Authors
Jiang, G.L. ; Huang, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cancer is essentially caused by alterations in
normal cellular genes. Multiple gene changes involving
at least two types of cancer genes, protooncogenes and
tumor suppressor genes, are required for the clonal
expansion of a malignant cell. This discussion focuses
on the recently recognized role of a small but expanding
family of PR-domain genes in tumorigenesis. The
protein products of these genes are involved in human
cancers in an unusual yin-yang fashion. Two products
are normally produced from a PR-domain family
member which differ by the presence or absence of the
PR domain; the PR-plus product is disrupted or
underexpressed whereas the PR-minus product is present
or overexpressed in cancer cells. This imbalance in the
amount of the two products, a result of either genetic or
epigenetic events, appears to be an important cause of
malignancy.
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