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Clinical significance of the pre-transplant CXCR3 and CCR6 expression on T cells In kidney graft recipients

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dc.contributor.authorAlfaro, Rafael
dc.contributor.authorLlorente, Santiago
dc.contributor.authorGonzález Martínez, Gema
dc.contributor.authorJiménez Coll, Víctor
dc.contributor.authorMartínez Banaclocha, Helios
dc.contributor.authorGalián, José Antonio
dc.contributor.authorBotella, Carmen
dc.contributor.authorMoya Quiles, María Rosa
dc.contributor.authorPeña Moral, Jesús de la
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorMuro, Manuel
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-08T11:39:17Z
dc.date.available2024-07-08T11:39:17Z
dc.date.issued2023-01-06
dc.description© 2022 The Author(s). This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Transplantation Proceedings. To access the final edited and published work see https://doi.org/10.1016/j.transproceed.2022.12.012
dc.description.abstractBackground. T cells play a fundamental role in the processes that mediate graft rejection, tolerance, and defense against infections. The CXCR3 and CCR6 receptors, highly expressed in Th1 (type 1 T helper cells)/Tc1 (T cytotoxic cells, type 1), Th1-Tc1, and Th17-Tc17 lymphocytes, respectively, participate in cell migration toward inflamed tissues. The altered expression level of CXCR3 and CCR6 has been associated with different clinical events after renal transplantation, such as acute rejection (AR) and chronic graft dysfunction, but data are still limited. In this study, we evaluated the expression of the receptor CXCR3 and CCR6 in peripheral blood T lymphocytes from kidney transplant recipients (KTR) and their association with viral infections, AR, and allograft function. Methods. Through flow cytometry, the peripheral blood expression of CXCR3 and CCR6 in T cells was evaluated in a pretransplant collection of KTR. The levels of these T subpopulations and their association with the incidence of AR, kidney graft function, viral infections, cytomegalovirus, and BK virus were studied. Adverse clinical events and graft function were monitored during the first year post transplant. Results. KTRs with low pretransplantation levels of Th17 (CD4+CXCR3-CCR6+) (tertile 1, Th17<16.4%) had a higher risk of suffering AR during the first year post transplantation (P = .033). KTRs with viral infections or reactivations during the first 3 months post transplantation had significantly lower levels of Tc17 (CD8+CXCR3-CCR6+) and higher levels of Th1 (CD4+CXCR3+CCR6-). In patients with cytomegalovirus reactivations, the viral peak correlates negatively with the pretransplant levels of Th1 (r = -0.606, P = .037). Conclusions. Pretransplantation assessment of Th1-Th17 and Tc1-Tc17 levels may help predict post-transplant clinical events such as AR and reactivation of viral infections.es
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dc.format.extent6es
dc.identifier.citationTransplantation Proceedings, 55, 66−71 (2023)
dc.identifier.doihttps://doi.org/10.1016/j.transproceed.2022.12.012
dc.identifier.issnPrint: 0041-1345
dc.identifier.issnElectronic: 1873-2623
dc.identifier.urihttp://hdl.handle.net/10201/142933
dc.languageenges
dc.publisherElsevier
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0041134522008831?via%3Dihub
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleClinical significance of the pre-transplant CXCR3 and CCR6 expression on T cells In kidney graft recipientses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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