Publication: Mother-fetus transference of lead and cadmium in rats, involvement of metallothionein
Loading...
Date
2009
Authors
Benitez, M.A. ; Méndez Armenta, M. ; Montes, S. ; Rembao, D. ; Sanin, L.H. ; Rios, C.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
This study was designed to assess the effect
of Cadmium (Cd) and lead (Pb) exposure during
pregnancy in rats and their correlation with
metallothionein (MT). Rats were exposed to either 10
ppm Cd or 300 ppm Pb through drinking water during
pregnancy. Both metals were measured in placenta, fetus
brain and fetal and maternal blood. MT was quantified in
placenta and fetus brain and it was also observed in
placenta by immunohistochemical technique. Offspring
weight was found to be significantly lower for the Cd
exposure group than for the control group. A Cd increase
in the placenta of the exposed group was accompanied
by MT induction; these effects were related to a limited
accumulation of Cd in fetus brain. In contrast, dam Pb
exposure caused an accumulation of Pb in the fetus brain
and induced damage to placenta. The results account for
differences in the transference of these metals during
pregnancy that could be related to their toxicity.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.