Publication: Influence of luteinizing hormone-releasing hormone LHRH, treatment on cellular proliferation in the rat anterior pituitary
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Date
1994
Authors
Carbajo, S. ; Gonzalez, F. ; López-Muñiz, A. ; Carbajo-Pérez, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study was designed to gain insight into
the action of LHRH on the control of cellular
proliferation in the anterior pituitary. The fraction of
cells labelled with bromodeoxyuridine (S-phase cells)
was studied in cytospin preparations of anterior pituitary
cells taken from control male and female rats and from
rats treated with daily doses of 2 pg1100 g body weight
of LHRH (7 days), with doses of 40 pg of LHRH given
on alternate days for 14 days (7 doses) or, finally, treated
with daily doses of 50 ng of busereline acetate (14 days).
Treatment with LHRH for 14 days resulted in a
significant increase in the fraction of S-phase cells.
However, neither the blockade of gonadotrophin
secretion with busereline acetate nor its stimulation with
LHRH for seven days resulted in a significant change in
the proliferative activity of anterior pituitary cells. This
action was independent of sex. No significant changes
were seen in the proportions of pituitary gonadotrops of
the different study groups. Regardless of the treatmentgroup
very few cells doubly-immunostained for BrdU
and LH were found. It is concluded that LHRH may
stimulate cellular proliferation in the anterior pituitary,
but further studies are needed to define which cells are
involved in this action.
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