Publication: Transactivation of Trk receptors in spinal motor neurons
Authors
Domeniconi, Marco ; Chao, Moses, V.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The neurotrophins are a family of trophic
factors that have been shown to have neuroprotective
effects after traumatic lesions of the nervous system and
in animal models of neurodegenerative diseases. They
mediate a broad spectrum of biological actions by
interacting with tyrosine kinase receptors (Trk). While
studies have demonstrated that neurotrophin
administration may have beneficial effects, there were
difficulties in delivering therapeutic quantities of these
factors to spinal motor neurons. We now describe a
strategy for applying transactivation of Trk receptors
using small molecules, such as adenosine, which can
penetrate the blood brain barrier and rescue motor
neurons from cell death. Transactivation opens up the
possibility of stimulating Trk receptors only in
populations of neurons that co-express both Trk and
adenosine receptors. We propose in this review to exploit
transactivation to improve the survival of motor neurons
in a transgenic mouse model of ALS and for other
neurodegenerative diseases, such as Alzheimer’s and
Huntington’s disease.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.