Extracellular matrix, biotensegrity and tumor microenvironment. An update and overview

Noguera, Rosa; Nieto, Olga Alicia; Tadeo, Irene; Fariñas, Fernando; Álvaro, Tomás

Publication:
Extracellular matrix, biotensegrity and tumor microenvironment. An update and overview

dc.contributor.author	Noguera, Rosa
dc.contributor.author	Nieto, Olga Alicia
dc.contributor.author	Tadeo, Irene
dc.contributor.author	Fariñas, Fernando
dc.contributor.author	Álvaro, Tomás
dc.date.accessioned	2017-03-13T15:07:29Z
dc.date.available	2017-03-13T15:07:29Z
dc.date.issued	2012
dc.description.abstract	The extracellular matrix (ECM) constitutes a three-dimensional network that surrounds all cells, organs and tissues in the body. It forms a biophysical filter for protection, nutrition and cell innervation, as well as the medium for facilitating immune response, angiogenesis, fibrosis and tissue regeneration. It is the mechanism by which mechanical forces are transmitted to the basement membrane which, through the integrins, supports the tensegrity system and activates the epigenetic mechanisms of the cell. A review and update on current knowledge on this topic reveals how disturbance of the ECM leads to a loss of efficient filtering, nutrition, elimination, and cell denervation functions, in addition to loss of regeneration capacity and disorders in mechanotransduction. Furthermore, such disturbance results in a loss of substrate, and with it the ability to provide a proper immune response against tumor, toxic and infectious agents. Reciprocal communication between ECM stromal and parenchymatous cells directs gene expression. The oncogenic capacity of the stroma derives from the associated cells as well as from the tumor cells, the angiogenic microenvironment and from an alteration in tensegrity; all of which are dependent on the ECM. It has been shown that the malignant phenotype is reversible by correction of the altered cues of the ECM.	es
dc.format	application/pdf	es
dc.format.extent	13	es
dc.identifier.citation	Histology and Histopatholy, Volume 27, number 6 (June), 2012
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/52444
dc.language	eng	es
dc.publisher	F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Extracellular matrix	es
dc.subject	Tensegrity	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología	es
dc.title	Extracellular matrix, biotensegrity and tumor microenvironment. An update and overview	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es