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Ascorbic acid deficiency accelerates aging of hepatic stellate cells with up-regulation of PPARγ

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dc.contributor.authorHong, Il-Hwa
dc.contributor.authorHan, Jung-Youn
dc.contributor.authorGoo, Moon-Jung
dc.contributor.authorHwa, Sung-Young
dc.contributor.authorKi, Mi-Ran
dc.contributor.authorPark, Jin-Kyu
dc.contributor.authorHong, Kyung-Sook
dc.contributor.authorHwang, Ok-Kyung
dc.contributor.authorKim, Tae-Hwan
dc.contributor.authorYoo, Sung-Eun
dc.contributor.authorJeong, Kyu-Shik
dc.date.accessioned2017-03-10T15:07:56Z
dc.date.available2017-03-10T15:07:56Z
dc.date.issued2012
dc.description.abstractSenescent cells have been observed in certain aged or damaged tissues. However, the information about the effects of aging on liver cells is limited. In the present study, we have examined age-related histological changes in the livers of senescence marker protein knockout (SMP30-/-) mice, which are considered as a murine aging model due to the more sensitive response to apoptotic reagents and due to their shorter life span. In livers of old SMP30-/- mice, numerous hepatic stellate cells (HSCs) were hypertrophic and contained abundant microvesicular lipid droplets in cytoplasm. We have found that the expression of peroxisome proliferators-activated receptor γ (PPARγ), which is a protein related to lipid metabolism and HSC quiescence, was increased in hypertrophic HSCs by aging and vitamin C (VC) deficiency, whereas these phenomena were dramatically reduced by antioxidant treatment. Therefore, these prominent phenotypic changes can be considered as aging markers in the livers of animals which are subjected to antioxidant property evaluationes
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 2 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52399
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAginges
dc.subjectAscorbic acides
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAscorbic acid deficiency accelerates aging of hepatic stellate cells with up-regulation of PPARγes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 2 (2012)