Publication: Growth factors in mechanisms
of malignancy: roles for TGF-í3 and FGF
Authors
Wright, J.A. ; Huang, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Malignant progression is a complex process
involving the accumulation of multiple genetic
alterations leading to changes in many specialized cell
functions. Important in this process is the loss of
growth control which is frequently associated with
modifications in growth factor production, and
growth factor response pathways. Indeed, oncogenes
have been characterized that code for polypeptide
growth factors or their receptors, and many tumor
cell populations release potently mitogenic growth
factors which contribute to the malignant properties of
tumor cells. In this review, the importance of growth
factors in mechanisms of malignant progression
is emphasized, using as examples the transforming
growth factor-beta (TGF-6) and fibroblast growth
factor (FGF) families. We describe many of the
properties and biological activities of these two families
of growth factors, focusing on mechanisms of autocrine
and intracrine mitogenic stimulation of tumor cell
proliferation and malignant progression. The discussion
includes evidence for altered growth factor expression
in tumor cells, and the relationship between these
changes in growth factors and alterations in the
regulation of DNA synthesis, cell proliferation, protease
production and cell motility required for invasion
and metastasis. Recent studies are described that show
that aberrant expression of TGF-BI, bFGF or K-FGF
results in dramatic changes in the genetic stability
of cells, leading to increased rates of spontaneous
gene amplification and the generation of drug
resistant variants. These findings describe new
malignancy relevant functions for altered growth factor
expression.
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