Publication: Differential microscopic finding and glucose
transporter 3 expression in terminal chorionic
villi among birth weight-discordant twin placentas
Authors
Lee, Mina ; Choi, Song-Yi ; Kang, Byung-Hun ; Yoo, Heon-Jong ; Song, Soo-Youn ; Seong, In-Ock ; Suh, Kwang-Sun ; Kim, Kyung-Hee
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10,14670/HH-11-600
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info:eu-repo/semantics/article
Description
Abstract
Objective: To evaluate differences in
microscopic findings and glucose transporter 3 (GLUT3)
expression in terminal chorionic villi (TV) among birth
weight-discordant twin (BWDT) placentas compared
with the birth weight-concordant twin (BWCT)
placentas.
Methods: We retrospectively studied a cohort of 26
BWDT, 10 BWCT, 10 pre-eclampsia singleton and 10
normal singleton pregnancies. Placentas were scored for
the percentage of TV, the percentage of TV with
syncytial knots, the presence of capillary branching
patterns of TV, the capillary to terminal villous ratios,
the membranous expression of GLUT3 and the nuclear
expression of HIF-1α in trophoblasts and capillary
endothelial cells of TV using immunohistochemistry.
The clinical characteristics and microscopic findings
were analyzed and compared.
Results: BWDT placentas exhibited differential
percentages of TV, percentages of TV with syncytial
knots, capillary to terminal villous ratios, expression of
HIF-1α in capillary endothelial cells and expression of
GLUT3 in trophoblasts and capillary endothelial cells of
TV among each twin pair compared with BWCT
placentas (P=0.003, P=0.022, P=0.037, P=0.007,
P=0.046 and P=0.002, respectively). Pre-eclampsia
singleton placentas exhibited higher GLUT3 expression
in trophoblasts, higher HIF-1α expression in capillary
endothelial cells of TV and high capillary to terminal
villous ratios compared with normal singleton placentas (P=0.001, P<0.001 and P=0.001, respectively).
Conclusions: We observed a strong relationship between
characteristics of adaptive change to hypoxia (GLUT3
expression, TV and syncytial knotting and higher
capillary to terminal villous ratios) and BWDT
pregnancy but not BWCT pregnancy.
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Citation
Histology and histopathology, Vol. 30, nº 8 (2015)
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