Autophagy and the regulation of the immune response

Macián, Fernando; Valdor Alonso, Rut

Publication:
Autophagy and the regulation of the immune response

dc.contributor.author	Macián, Fernando
dc.contributor.author	Valdor Alonso, Rut
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2025-01-17T12:21:58Z
dc.date.available	2025-01-17T12:21:58Z
dc.date.issued	2012-12
dc.description	© 2012 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted Manuscript version of a Published Work that appeared in final form in Pharmacological Research. To access the final edited and published work see https://doi.org/10.1016/j.phrs.2012.10.003
dc.description.abstract	Autophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays a crucial role in maintaining cellular homeostasis by recycling amino acids, reducing the amount of damaged proteins and regulating protein levels in response to extracellular signals. In the last few years specific functions for different forms of autophagy have been identified in many tissues and organs. In the Immune System, autophagy functions range from the elimination infectious agents and the modulation of the inflammatory response, to the selection of antigens for presentation and the regulation of T cell homeostasis and activation. Here, we review the recent advances that have allowed us to better understand why autophagy is a crucial process in the regulation of the innate and adaptive immune responses.
dc.format	application/pdf	es
dc.identifier.citation	Pharmacological Research, 2012, Vol. 66, Issue 6, pp. 475-483
dc.identifier.doi	https://doi.org/10.1016/j.phrs.2012.10.003
dc.identifier.issn	Print: 1043-6618
dc.identifier.issn	Electronic: 1096-1186
dc.identifier.uri	http://hdl.handle.net/10201/148693
dc.language	eng	es
dc.relation	National Institutes of Health/National Institute on Aging and the National Institute of Allergy and Infectious Diseases (to FM; AG031782),	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S1043661812001909
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Autophagy
dc.subject	T cell
dc.subject	Dendritic cell
dc.subject	Antigen presentation
dc.subject	Macrophage
dc.subject	Pathogen
dc.title	Autophagy and the regulation of the immune response	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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