Publication: Apoptosis of the cerebellar neurons
Authors
Lossi, Laura ; Gambino, Graziana
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Naturally occurring neuronal death (NOND)
is an essential phenomenon during the course of normal
development of the nervous system. Studies in vivo and
on organotypic cultures have helped to elucidate the
basic histological and ultrastructural features, as well as
the main cellular mechanisms of NOND in several areas
of the brain. This review examines the existing evidence
about the two waves of apoptotic cell death that affect
the different types of cerebellar neurons in normal
development and certain pathological conditions. The
first wave regards neuronal progenitors and premigratory
neuroblasts, the second post-migratory
neuroblasts and mature neurons. The underlying cellular
and molecular mechanisms are discussed critically also
in the light of their relevance to neurodegenerative
diseases.
Citation
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