Publication: Cells with morphological and immunohistochemical features of hepatic stellate cells (Ito cells) form an extralittoral (extrasinusoidal) compartment in the cirrhotic rat liver
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Date
1999
Authors
Zimmermann, Astrid ; Zimmermann, H. ; Fellay, M. ; Reichen, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Systematic studies on hepatic stellate cells
and myofibroblasts have so far mainly focused on cells
located in the perisinusoidal space of Disse, the so-called
littoral compartment. Here, these cells play a key role for
intralobular fibrogenesis and sinusoidal capillarization.
However, advanced hepatic fibrosis and cirrhosis are
characterized by portal tract fibrosis and septal fibrosis,
thus involving cells outside the perisinusoidal space. To
study the question as to whether hepatic stellate cells
occur and are expanded in an extralittoral (extrasinusoidal)
compartment in cirrhogenesis, we systematically
analyzed the distribution and density of desminreactive
stellate cells in a rat model of hepatic fibrosis.
Fibrosis and remodeling of the liver were induced by
bile duct ligation, and stellate cells were identified by
single and double immunohistochemistry. We can show
that desmin-reactive cells are reproducibly detectable in
extralittoral compartments of the normal and fibrotic rat
liver. Periductular extralittoral stellate cells are
significantly more frequent in cirrhosis, indicating that
extralittoral stellate cells expand in concert with
proliferating ductules. The findings suggest that ductular
proliferation thought to represent a pacemaker of hepatic
remodeling is accompanied by a population of cells
exhibiting the same phenotype as perisinusoidal stellate
cells
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