Publication: New aspects of the pathogenesis
of osteoarthritis: the role of fibroblast-like
chondrocytes in late stages of the disease
Authors
Tesche, F. ; Miosge, Nicolai
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
It is thought that the general increase in life
expectancy will make osteoarthritis the fourth leading
cause of disability by the year 2020. Even though the
pathogenesis of idiopathic osteoarthritis has not been
fully elucidated, the main features of the disease process
are the altered interactions between the chondrocytes
and their surrounding extracellular matrix. In the course
of these disturbances, three types of chondrocytes are
typically present in the pathologically altered
extracellular matrix of the articular cartilage: healthy
chondrocytes which are continually undergoing
degeneration, degenerated cells which are continually
being degraded and finally fibroblast-like chondrocytes
which seem not to be influenced by this process and,
therefore, are found in ever-increasing numbers. These
fibroblast-like chondrocytes take part in tissue
regeneration even in advanced stages of osteoarthritis,
but only in as much as they form fibrocartilaginous or
scar tissue, since, as we were able to show, they mainly
synthesize collagen type I and not collagen type II,
typical for healthy cartilage. However, we were further
able to show that fibroblast-like chondrocytes also
produce increasing amounts of the proteoglycans decorin
and biglycan which physiologically are involved in the
formation of collagen type II, as well as perlecan. These
multifunctional fibroblast-like chondrocytes could
present an ideal therapeutic starting point if they could
be modified to synthesize the collagen type II typical for
cartilage and to, thereby, contribute to reversing the
damage of the joint cartilage that has occurred by the
late stages of osteoarthritis.
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