Publication:
Current knowledge of pituitary adenylate cyclase activating polypeptide (PACAP) in articular cartilage

Simple item page
dc.contributor.authorLauretta, Giovanni
dc.contributor.authorRavalli, Silvia
dc.contributor.authorSzychlinska, Marta Anna
dc.contributor.authorCastorina, Alessandro
dc.contributor.authorMaugeri, Grazia
dc.contributor.authorD'Amico, Agata Grazia
dc.contributor.authorD'Agata, Velia
dc.contributor.authorMusumeci, Giuseppe
dc.date.accessioned2022-12-14T09:44:31Z
dc.date.available2022-12-14T09:44:31Z
dc.date.issued2020
dc.description.abstractPituitary adenylate cyclase activating polypeptide (PACAP) is an evolutionally well conserved neuropeptide, mainly expressed by neuronal and peripheral cells. It proves to be an interesting object of study both for its trophic functions during the development of several tissues and for its protective effects against oxidative stress, hypoxia, inflammation and apoptosis in different degenerative diseases. This brief review summarises the recent findings concerning the role of PACAP in the articular cartilage. PACAP and its receptors are expressed during chondrogenesis and are shown to activate the pathways involved in regulating cartilage development. Moreover, this neuropeptide proves to be chondroprotective against those stressors that determine cartilage degeneration and contribute to the onset of osteoarthritis (OA), the most common form of degenerative joint disease. Indeed, the degenerated cartilage exhibits low levels of PACAP, suggesting that its endogenous levels in adult cartilage may play an essential role in maintaining physiological properties. Thanks to its peculiar characteristics, exogenous administration of PACAP could be suggested as a potential tool to slow down the progression of OA and for cartilage regeneration approaches.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 35, nº11 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-233
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/126423
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectArticular cartilagees
dc.subjectCartilage regenerationes
dc.subjectChondrogenesises
dc.subjectOsteoarthritises
dc.subjectPACAPes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCurrent knowledge of pituitary adenylate cyclase activating polypeptide (PACAP) in articular cartilagees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Lauretta-35-1251-1262-2020.pdf
Size:
1.57 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.35,nº11 (2020)