Publication: Synthesis of Cellulose Nanoparticles from Ionic Liquid Solutions for Biomedical Applications
Authors
Fuster, M. G. ; Moulefera, I. ; Muñoz, M. N. ; Montalbán, M. G. ; Víllora Cano, Gloria
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Facultad de Química
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Publisher
MDPI
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DOI
https://doi.org/10.3390/polym15020382
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info:eu-repo/semantics/article
Description
© 2023 by the authors____ This document is the published version of a published work that appeared in final form in Polymers ____
This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 ____
To access the final edited and published work see:
https://doi.org/10.3390/polym15020382
Abstract
A method for the synthesis of cellulose nanoparticles using the ionic liquid 1-ethyl-3-
methylimidazolium acetate has been optimised. The use of a highly biocompatible biopolymer
such as cellulose, together with the use of an ionic liquid, makes this method a promising way
to obtain nanoparticles with good capability for drug carrying. The operating conditions of the
synthesis have been optimised based on the average hydrodynamic diameter, the polydispersity
index, determined by Dynamic Light Scattering (DLS) and the Z-potential, obtained by phase analysis
light scattering (PALS), to obtain cellulose nanoparticles suitable for use in biomedicine. The obtained
cellulose nanoparticles have been characterised by Fourier transform infrared spectroscopy (FTIR)
with attenuated total reflectance (ATR), field emission scanning electron microscopy (FESEM) and
thermogravimetric analysis (TGA/DTA). Finally, cell viability studies have been performed with a
cancer cell line (HeLa) and with a healthy cell line (EA.hy926). These have shown that the cellulose
nanoparticles obtained are not cytotoxic in the concentration range of the studied nanoparticles. The
results obtained in this work constitute a starting point for future studies on the use of cellulose
nanoparticles, synthesised from ionic liquids, for biomedical applications such as targeted drug
release or controlled drug release.
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Citation
Polymers 2023, 15(2), 382
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