Correlated color temperature and light intensity: Complementary features in nonvisual light field

Arguelles-Prieto, Raquel; Madrid, Juan Antonio; Rol, Maria-Angeles; Bonmatí Carrión, María de los Ángeles

Publication:
Correlated color temperature and light intensity: Complementary features in nonvisual light field

dc.archivorevisado	Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Anatomía Humana y Psicobiología
dc.contributor.author	Arguelles-Prieto, Raquel
dc.contributor.author	Madrid, Juan Antonio
dc.contributor.author	Rol, Maria-Angeles
dc.contributor.author	Bonmatí Carrión, María de los Ángeles
dc.contributor.department	Anatomía Humana y Psicobiología
dc.date.accessioned	2025-02-01T23:26:16Z
dc.date.available	2025-02-01T23:26:16Z
dc.date.issued	2021-07-12
dc.description	© 2021 Arguelles-Prieto et al. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript, version of a Published Work that appeared in final form in PLoS ONE. To access the final edited and published work see https://doi.org/10.1371/journal.pone.0254171
dc.description.abstract	An appropriate exposure to the light-dark cycle, with high irradiances during the day and darkness during the night is essential to keep our physiology on time. However, considering the increasing exposure to artificial light at night and its potential harmful effects on health (i.e. chronodisruption and associated health conditions), it is essential to understand the non-visual effects of light in humans. Melatonin suppression is considered the gold standard for nocturnal light effects, and the activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) through the assessment of pupillary light reflex (PLR) has been recently gaining attention. Also, some theoretical models for melatonin suppression and retinal photoreceptors activation have been proposed. Our aim in this study was to determine the influence of correlated color temperature (CCT) on melatonin suppression and PLR, considering two commercial light sources, as well as to explore the possible correlation between both processes. Also, the contribution of irradiance (associated to CCT) was explored through mathematical modelling on a wider range of light sources. For that, melatonin suppression and PLR were experimentally assessed on 16 healthy and young volunteers under two light conditions (warmer, CCT 3000 K; and cooler, CCT 5700 K, at ~5·1018 photons/cm2/sec). Our experimental results yielded greater post-stimulus constriction under the cooler (5700 K, 13.3 ± 1.9%) than under the warmer light (3000 K, 8.7 ± 1.2%) (p < 0.01), although no significant differences were found between both conditions in terms of melatonin suppression. Interestingly, we failed to demonstrate correlation between PLR and melatonin suppression. Although methodological limitations cannot be discarded, this could be due to the existence of different subpopulations of Type 1 ipRGCs differentially contributing to PLR and melatonin suppression, which opens the way for further research on ipRGCs projection in humans. The application of theoretical modelling suggested that CCT should not be considered separately from irradiance when designing nocturnal/diurnal illumination systems. Further experimental studies on wider ranges of CCTs and light intensities are needed to confirm these conclusions.
dc.format	application/pdf	es
dc.identifier.citation	PLoS ONE, 2021, Vol. 16, Issue 7 : e0254171
dc.identifier.doi	https://doi.org/10.1371/journal.pone.0254171
dc.identifier.issn	Electronic: 1932-6203
dc.identifier.uri	http://hdl.handle.net/10201/149947
dc.language	eng	es
dc.publisher	Public Library of Science
dc.relation	This work was supported by the Ministry of Economy and Competitiveness, the Instituto de Salud Carlos III through a CIBERFES grant (CB16/ 10/00239), Fundacio´n Se´neca through grant 19899/GERM/15 awarded to JAM; the Ministry of Science, Innovation and Universities and Agencia Estatal de Investigacio´n through grant RTI2018- 093528-B-I00 and Diabfrail LatAm (European Union’s Horizon 2020 research and innovation programme No 825546) awarded to MAR (all of them co-financed by FEDER). Research fellowship granted to MAB-C (20401/SF/17. Fundacio´n Séneca. Región de Murcia (Spain)) and to RA-P (FPU13/01421) by Ministry of Education, Culture and Sports.	es
dc.relation.publisherversion	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254171
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.title	Correlated color temperature and light intensity: Complementary features in nonvisual light field	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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