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Morphological, immunohistochemical and ultrastrucmturaclh anges in dimenthylnimtrosamine induced liver injury. Effect of malotilate

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dc.contributor.authorStenbäck, F.
dc.contributor.authorAla-Kokko, L.
dc.contributor.authorRyhänen, L.
dc.date.accessioned2011-01-18T08:55:27Z
dc.date.available2011-01-18T08:55:27Z
dc.date.issued1989
dc.description.abstractSummary. Dimethylnitrosarnine (DMN) induced liver injurq in rats with cell necrosis, inflammation, hemorrhages, increased collagen type 111 synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased interstitial collagen deposits and vascularization. 1 t affected clearly less DMN-caused hemorrhage. When malotilate treatment was started subsequently to development of DMN-injury, it also caused decrease in inflammation, though less, as well as in collagen 111, BM and fibronectin deposits. We suggest that the mode of the malotilate effect on reducing the DMN-induced fibrosis of the liver is via inhibiting the inflammation. decreased fibronectin deposition possibly also playing a role.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/17959
dc.languageenges
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDimethylnitrosamine, Malotilatees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleMorphological, immunohistochemical and ultrastrucmturaclh anges in dimenthylnimtrosamine induced liver injury. Effect of malotilatees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 4, nº 1 (1989)