Publication: Localization of blood coagulation factors in the germinal centers of human Peyer's patches
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Date
1992
Authors
Kudo, S. ; Yamakawa, Mitsunori ; Imai, Yutaka ; Tsukamoto, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The immunohistochemical distribution of
15 blood coagulation factors in the germinal centers
(GCs) of human Peyer's patches (PPs) was studied.
Although factor VIII, active alpha-thrombin, and
fibrinogen were hardly evident in the GCs, the
majority of coagulation factors, such as kallikrein,
high-molecular-weight kininogen, factos XII, X, IX,
VII, V, XIIIa and XIIIb, prothrombin, anti-thrombin
111 and inactive alpha-thrombin were found, showing a
lace-like staining pattern similar to that obtained with
a monoclonal antibody, R4123, specific for follicular
dendritic cells (FDCs) in the GCs. By immunoelectron
microscopy, positive reactions for factor X and XIIIa
were found on the surfaces of FDCs, GC cells, andlor
in the intercellular spaces of GCs, being especially
marked on the surface of the labyrinth-like structure
of FDCs. It is concluded that a majority of coagulation
factors are localized in the GCs of human PPs.
Furthermore, it is suggested that some of these
coagulation factors have a close topographical
relationship with FDCs.
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