Publication: Pax genes in myogenesis:
Alternate transcripts add complexity
Authors
Lamey, T.M. ; Koenders, A. ; Ziman, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Pax3 and Pax7 are powerful myogenic
inducers and hence play a critical role in skeletal muscle
development and regeneration. In this paper we discuss
the role of Pax3 and Pax7 in dorsal patterning of the
somite with subsequent determination of myogenic
precursor cells for muscle formation within the
developing embryo and in adult muscle. Recent evidence
of the ability of stem cells to contribute to muscle
regeneration in adult tissues, and the role of Pax7 in
conversion of multipotent stem cells to the myogenic
lineage are also discussed.
Several tissue specific Pax7 transcripts that encode
isoforms with different DNA binding characteristics and
potentially distinct transactivation specificities are
identified. The expression of a range of transcripts in the
determination of different tissue lineages and distinct
cell populations both in the embryo and in the adult
indicates an extraordinary level of complexity. A
detailed understanding of these molecules and their
functions during embryogenesis and adult muscle
formation is imperative for future stem cell therapies.
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