Publication:
The role of KMT2 gene in human tumors

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Zhang-37-323-334-2022.pdf(1.48 MB)
Date
2022
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Authors
Zhang, Zhi Long ; Yu, Peng Fei ; Ling, Zhi Qiang
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-447
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info:eu-repo/semantics/article
Description
Abstract
Histone methylation plays a crucial role in the regulation of gene transcriptional expression, and aberration of methylation-modifying enzyme genes can lead to a variety of genetic diseases, including human cancers. The histone modified protein KMT2 (lysin methyltransferase) family are involved in cell proliferation, growth, development and differentiation through regulating gene expression, and are closely related with many blood cancers and solid tumors. In recent years, several studies have shown that mutations in the KMT2 gene occur frequently in a variety of human cancers and the mutation status of the KMT2 gene may be correlated with the occurrence, development and prognosis of some tumors. Research uncovering the clinical characteristics and molecular mechanisms of KMT2 mutation in human tumors will be helpful for early diagnosis and prognosis of tumors as well as drug development for targeted therapies.
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KMT2A , KMT2C , KMT2D , Gene mutation , Tumorigenesis
Citation
Histology and Histopathology Vol. 37, nº4 (2022)
URI
http://hdl.handle.net/10201/128406
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Histology and histopathology Vol.37, nº4 (2022)
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